Drug interactions
Azithromycin + Ruxolitinib
Severity: Minor
Azithromycin and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azithromycin is only a weak or negligible CYP3A4 inhibitor, so any increase in ruxolitinib exposure is unlikely to be clinically meaningful. Ruxolitinib labeling concerns strong CYP3A4 inhibitors, which azithromycin is not.
What this interaction means in plain words
Azithromycin and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azithromycin belongs to Anti Bacterial; Ruxolitinib belongs to Oncology.
Why it happens
Possible minor CYP3A4 inhibition, which is weak and of doubtful clinical relevance.
What to do
No dose adjustment is needed. Monitor blood counts as routinely done for ruxolitinib therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Azithromycin with Ruxolitinib?
MediHelp rates the interaction as minor. Azithromycin and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azithromycin is only a weak or negligible CYP3A4 inhibitor, so any increase in ruxolitinib exposure is unlikely to be clinically meaningful. Ruxolitinib labeling concerns strong CYP3A4 inhibitors, which azithromycin is not.
How serious is the interaction between Azithromycin and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor blood counts as routinely done for ruxolitinib therapy.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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