Drug interactions
Azithromycin + Sevoflurane
Severity: Moderate
Azithromycin and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane prolongs the QT interval and azithromycin has comparable effects. Combined perioperative use may raise the risk of torsades de pointes, particularly with electrolyte disturbance.
What this interaction means in plain words
Azithromycin and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive QTc prolongation via effects on cardiac repolarization.
What to do
Check baseline ECG and correct potassium and magnesium before anesthesia. Monitor the ECG during the procedure in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Azithromycin with Sevoflurane?
MediHelp rates the interaction as moderate. Azithromycin and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane prolongs the QT interval and azithromycin has comparable effects. Combined perioperative use may raise the risk of torsades de pointes, particularly with electrolyte disturbance.
How serious is the interaction between Azithromycin and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium before anesthesia. Monitor the ECG during the procedure in patients with other QT risk factors.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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