Drug interactions
Azithromycin + Tiotropium-olodaterol
Severity: Moderate
Azithromycin and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azithromycin can prolong the QT interval, and olodaterol may add to arrhythmic risk through tachycardia and hypokalemia. The risk is greater in patients with electrolyte disturbances, structural heart disease or other QT-prolonging drugs.
What this interaction means in plain words
Azithromycin and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta2-agonist-induced hypokalemia and tachycardia.
What to do
Correct potassium and magnesium and consider an ECG in patients with cardiac risk factors; use an alternative antibiotic if QT risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Azithromycin and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azithromycin can prolong the QT interval, and olodaterol may add to arrhythmic risk through tachycardia and hypokalemia. The risk is greater in patients with electrolyte disturbances, structural heart disease or other QT-prolonging drugs.
How serious is the interaction between Azithromycin and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium and consider an ECG in patients with cardiac risk factors; use an alternative antibiotic if QT risk is high.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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