Drug interactions
Azithromycin + Trazodone
Severity: Moderate
Azithromycin and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combined use may increase the risk of torsades de pointes. The concern is highest in patients with heart disease, bradycardia or electrolyte abnormalities.
What this interaction means in plain words
Azithromycin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Trazodone belongs to Central Nervous System.
Why it happens
Additive QT prolongation via hERG potassium channel blockade.
What to do
Check baseline QTc and correct hypokalemia and hypomagnesemia. Monitor the ECG and avoid the combination in patients with long QT syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Azithromycin with Trazodone?
MediHelp rates the interaction as moderate. Azithromycin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so combined use may increase the risk of torsades de pointes. The concern is highest in patients with heart disease, bradycardia or electrolyte abnormalities.
How serious is the interaction between Azithromycin and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline QTc and correct hypokalemia and hypomagnesemia. Monitor the ECG and avoid the combination in patients with long QT syndrome.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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