Drug interactions
Azithromycin + Trimipramine
Severity: Moderate
Azithromycin and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as trimipramine can lengthen the QT interval, and azithromycin has a similar effect. Together they may increase the likelihood of serious ventricular arrhythmias.
What this interaction means in plain words
Azithromycin and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Trimipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation through blockade of cardiac potassium channels.
What to do
Obtain a baseline ECG, correct electrolyte abnormalities, and monitor the QTc during the antibiotic course. Choose an alternative antibiotic in patients with prolonged QTc or structural heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Azithromycin with Trimipramine?
MediHelp rates the interaction as moderate. Azithromycin and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants such as trimipramine can lengthen the QT interval, and azithromycin has a similar effect. Together they may increase the likelihood of serious ventricular arrhythmias.
How serious is the interaction between Azithromycin and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, correct electrolyte abnormalities, and monitor the QTc during the antibiotic course. Choose an alternative antibiotic in patients with prolonged QTc or structural heart disease.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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