Drug interactions
Azithromycin + Valbenazine
Severity: Moderate
Azithromycin and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine can prolong the QT interval at higher exposures, and azithromycin has a known QT-prolonging effect. Taken together they may increase the chance of ventricular arrhythmia, especially in patients with other risk factors.
What this interaction means in plain words
Azithromycin and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Valbenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation through pharmacodynamic effects on cardiac repolarization.
What to do
Check a baseline ECG and electrolytes in patients with cardiac risk factors and monitor the QTc during the antibiotic course. Consider an alternative antibiotic in patients with congenital long QT or significant heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Azithromycin with Valbenazine?
MediHelp rates the interaction as moderate. Azithromycin and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine can prolong the QT interval at higher exposures, and azithromycin has a known QT-prolonging effect. Taken together they may increase the chance of ventricular arrhythmia, especially in patients with other risk factors.
How serious is the interaction between Azithromycin and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes in patients with cardiac risk factors and monitor the QTc during the antibiotic course. Consider an alternative antibiotic in patients with congenital long QT or significant heart disease.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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