Drug interactions
Aztreonam + Dicloxacillin
Severity: Minor
Aztreonam and Dicloxacillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a penicillin with aztreonam can give complementary coverage because aztreonam acts only on aerobic gram-negative bacteria while dicloxacillin covers gram-positive organisms. This is a spectrum complement rather than a harmful interaction, and no safety concern is expected.
What this interaction means in plain words
Aztreonam and Dicloxacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aztreonam belongs to Anti Bacterial; Dicloxacillin belongs to Anti Bacterial.
Why it happens
Complementary or additive beta-lactam activity at different penicillin-binding proteins in different bacterial groups.
What to do
No action is needed beyond selecting doses suited to the infection and renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Other interactions of Aztreonam
- Aztreonam + Cefoxitin Moderate
- Aztreonam + Cholera vaccine Moderate
- Aztreonam + Microbiota Moderate
- Aztreonam + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Aztreonam + Typhoid vaccine live Moderate
- Amikacin + Aztreonam Minor
Frequently asked questions
Can I take Aztreonam with Dicloxacillin?
MediHelp rates the interaction as minor. Aztreonam and Dicloxacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combining a penicillin with aztreonam can give complementary coverage because aztreonam acts only on aerobic gram-negative bacteria while dicloxacillin covers gram-positive organisms. This is a spectrum complement rather than a harmful interaction, and no safety concern is expected.
How serious is the interaction between Aztreonam and Dicloxacillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond selecting doses suited to the infection and renal function.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Axitinib. The full list is on the Dicloxacillin page.
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