Drug interactions
Aztreonam + Gentamicin
Severity: Minor
Aztreonam and Gentamicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aztreonam and gentamicin are often combined for serious gram-negative infections, including Pseudomonas aeruginosa, and show additive or synergistic antibacterial effects. The combination is usually intentional, but aminoglycoside nephrotoxicity and ototoxicity still require attention.
What this interaction means in plain words
Aztreonam and Gentamicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aztreonam belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.
Why it happens
Beta-lactam damage to the cell wall enhances aminoglycoside uptake, producing synergistic bacterial killing.
What to do
Monitor renal function and gentamicin serum concentrations, and adjust dosing to renal function. Reassess the need for the aminoglycoside once susceptibilities are known.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aztreonam
- Aztreonam + Cefoxitin Moderate
- Aztreonam + Cholera vaccine Moderate
- Aztreonam + Microbiota Moderate
- Aztreonam + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Aztreonam + Typhoid vaccine live Moderate
- Amikacin + Aztreonam Minor
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Aztreonam with Gentamicin?
MediHelp rates the interaction as minor. Aztreonam and Gentamicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aztreonam and gentamicin are often combined for serious gram-negative infections, including Pseudomonas aeruginosa, and show additive or synergistic antibacterial effects. The combination is usually intentional, but aminoglycoside nephrotoxicity and ototoxicity still require attention.
How serious is the interaction between Aztreonam and Gentamicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and gentamicin serum concentrations, and adjust dosing to renal function. Reassess the need for the aminoglycoside once susceptibilities are known.
What other medicines interact with Aztreonam?
MediHelp also lists interactions of Aztreonam with, for example, Cefoxitin, Cholera vaccine, Microbiota. The full list is on the Aztreonam page.
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