Drug interactions
Baclofen + Dantrolene
Severity: Moderate
Baclofen and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs reduce muscle tone and cause drowsiness, dizziness and weakness. Used together, sedation and muscle weakness may be additive, and dantrolene also carries a risk of liver toxicity.
What this interaction means in plain words
Baclofen and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive CNS depression and muscle weakness from baclofen (central GABA-B agonism) and dantrolene (inhibition of skeletal muscle calcium release).
What to do
Monitor for sedation, excessive weakness and falls, and adjust doses to the lowest effective level. Continue routine liver function monitoring for dantrolene.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Baclofen and Dantrolene, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Baclofen
Other interactions of Dantrolene
Frequently asked questions
Can I take Baclofen with Dantrolene?
MediHelp rates the interaction as moderate. Baclofen and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs reduce muscle tone and cause drowsiness, dizziness and weakness. Used together, sedation and muscle weakness may be additive, and dantrolene also carries a risk of liver toxicity.
How serious is the interaction between Baclofen and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, excessive weakness and falls, and adjust doses to the lowest effective level. Continue routine liver function monitoring for dantrolene.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
