Drug interactions
Baclofen + Mirtazapine
Severity: Moderate
Baclofen and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine is strongly sedating, particularly at low doses, and adds to the drowsiness and dizziness of baclofen. Older patients may be at greater risk of confusion and falls.
What this interaction means in plain words
Baclofen and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-B agonism and H1 antihistaminic effect of mirtazapine.
What to do
Monitor sedation and counsel on driving and fall risk. Consider taking mirtazapine at bedtime and adjust doses if daytime drowsiness persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Baclofen and Mirtazapine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Baclofen
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Baclofen with Mirtazapine?
MediHelp rates the interaction as moderate. Baclofen and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirtazapine is strongly sedating, particularly at low doses, and adds to the drowsiness and dizziness of baclofen. Older patients may be at greater risk of confusion and falls.
How serious is the interaction between Baclofen and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and counsel on driving and fall risk. Consider taking mirtazapine at bedtime and adjust doses if daytime drowsiness persists.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
