Drug interactions
Baclofen + Oxycodone
Severity: Moderate
Baclofen and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baclofen is a CNS depressant, and combining it with oxycodone may increase sedation, dizziness, hypotension and respiratory depression. Risk is greater in older or renally impaired patients.
What this interaction means in plain words
Baclofen and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects via GABA-B agonism and opioid receptor activity.
What to do
Start with low doses and monitor for sedation and respiratory depression. Reduce baclofen or oxycodone doses if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Baclofen
Frequently asked questions
Can I take Baclofen with Oxycodone?
MediHelp rates the interaction as moderate. Baclofen and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Baclofen is a CNS depressant, and combining it with oxycodone may increase sedation, dizziness, hypotension and respiratory depression. Risk is greater in older or renally impaired patients.
How serious is the interaction between Baclofen and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor for sedation and respiratory depression. Reduce baclofen or oxycodone doses if excessive drowsiness occurs.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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