Drug interactions
Baclofen + Risperidone
Severity: Moderate
Baclofen and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Co-administration may increase drowsiness, dizziness and orthostatic hypotension, raising the risk of falls. Both drugs can also lower seizure threshold, which may matter in susceptible patients.
What this interaction means in plain words
Baclofen and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension from GABA-B agonism and risperidone's H1 and alpha-1 adrenergic antagonism.
What to do
Use the lowest effective doses and monitor sedation and orthostatic blood pressure, especially in older adults. Counsel patients to rise slowly and avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Baclofen with Risperidone?
MediHelp rates the interaction as moderate. Baclofen and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Co-administration may increase drowsiness, dizziness and orthostatic hypotension, raising the risk of falls. Both drugs can also lower seizure threshold, which may matter in susceptible patients.
How serious is the interaction between Baclofen and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and orthostatic blood pressure, especially in older adults. Counsel patients to rise slowly and avoid alcohol.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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