Drug interactions
Baclofen + Sevoflurane
Severity: Moderate
Baclofen and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baclofen may enhance the effect of volatile anesthetics such as sevoflurane, leading to deeper sedation, hypotension and respiratory depression. Patients on high-dose oral or intrathecal baclofen may need less anesthetic.
What this interaction means in plain words
Baclofen and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-B agonism and volatile anesthetic potentiation of inhibitory neurotransmission.
What to do
Titrate the anesthetic to clinical effect and depth monitoring, and watch blood pressure and ventilation. Continue baclofen perioperatively as advised to avoid withdrawal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Sevoflurane
Frequently asked questions
Can I take Baclofen with Sevoflurane?
MediHelp rates the interaction as moderate. Baclofen and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Baclofen may enhance the effect of volatile anesthetics such as sevoflurane, leading to deeper sedation, hypotension and respiratory depression. Patients on high-dose oral or intrathecal baclofen may need less anesthetic.
How serious is the interaction between Baclofen and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate the anesthetic to clinical effect and depth monitoring, and watch blood pressure and ventilation. Continue baclofen perioperatively as advised to avoid withdrawal.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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