Drug interactions
Baclofen + Trazodone
Severity: Moderate
Baclofen and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone is sedating and can cause orthostatic hypotension, and baclofen adds to drowsiness and dizziness. Together they may impair alertness and raise fall risk, especially in older adults.
What this interaction means in plain words
Baclofen and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-B agonism and trazodone H1 and alpha-1 antagonism.
What to do
Start with low doses, titrate slowly, and monitor for excessive sedation and orthostasis. Advise against driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Baclofen with Trazodone?
MediHelp rates the interaction as moderate. Baclofen and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone is sedating and can cause orthostatic hypotension, and baclofen adds to drowsiness and dizziness. Together they may impair alertness and raise fall risk, especially in older adults.
How serious is the interaction between Baclofen and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses, titrate slowly, and monitor for excessive sedation and orthostasis. Advise against driving until tolerance is established.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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