Drug interactions
Baloxavir marboxil + Magnesium hydroxide
Severity: Moderate
Baloxavir marboxil and Magnesium hydroxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baloxavir can chelate polyvalent cations such as magnesium in the gut, which may reduce its absorption and antiviral exposure. This could lessen treatment effectiveness for influenza.
What this interaction means in plain words
Baloxavir marboxil and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baloxavir marboxil belongs to Anti Virals; Magnesium hydroxide belongs to Gastrointestinal Tract.
Why it happens
Chelation of baloxavir by polyvalent cations in the gastrointestinal tract reduces absorption.
What to do
Avoid taking baloxavir with magnesium-containing antacids or laxatives. If needed, give baloxavir at least 2 hours apart from the antacid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium hydroxide
Other interactions of Baloxavir marboxil
- Aluminum hydroxide + Baloxavir marboxil Moderate
- Baloxavir marboxil + Calcium Moderate
- Baloxavir marboxil + Calcium carbonate Moderate
- Baloxavir marboxil + Carbonyl iron Moderate
- Baloxavir marboxil + Ferrous fumarate Moderate
- Baloxavir marboxil + Ferrous gluconate Moderate
Frequently asked questions
Can I take Baloxavir marboxil with Magnesium hydroxide?
MediHelp rates the interaction as moderate. Baloxavir marboxil and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Baloxavir can chelate polyvalent cations such as magnesium in the gut, which may reduce its absorption and antiviral exposure. This could lessen treatment effectiveness for influenza.
How serious is the interaction between Baloxavir marboxil and Magnesium hydroxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking baloxavir with magnesium-containing antacids or laxatives. If needed, give baloxavir at least 2 hours apart from the antacid.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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