Drug interactions
Balsalazide + Paromomycin
Severity: Minor
Balsalazide and Paromomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Balsalazide depends on colonic bacteria to release mesalamine. Oral paromomycin is poorly absorbed and acts in the gut lumen, where it could reduce bacterial activation of the prodrug and potentially lessen its local effect.
What this interaction means in plain words
Balsalazide and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Balsalazide belongs to Gastrointestinal Tract; Paromomycin belongs to Anti Bacterial.
Why it happens
Luminal antibacterial activity of paromomycin may decrease bacterial azoreductase-mediated cleavage of balsalazide.
What to do
No routine adjustment is needed; reassess colitis symptoms if control worsens during paromomycin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Balsalazide
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Balsalazide with Paromomycin?
MediHelp rates the interaction as minor. Balsalazide and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Balsalazide depends on colonic bacteria to release mesalamine. Oral paromomycin is poorly absorbed and acts in the gut lumen, where it could reduce bacterial activation of the prodrug and potentially lessen its local effect.
How serious is the interaction between Balsalazide and Paromomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; reassess colitis symptoms if control worsens during paromomycin therapy.
What other medicines interact with Balsalazide?
MediHelp also lists interactions of Balsalazide with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Balsalazide page.
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