Drug interactions
Bazedoxifene-conjugated estrogens + Levoketoconazole
Severity: Major
Bazedoxifene-conjugated estrogens and Levoketoconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and can substantially increase exposure to the estrogen component and possibly bazedoxifene. This raises the risk of estrogen-related adverse effects, including endometrial stimulation and thromboembolic concerns.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Levoketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Levoketoconazole belongs to Endocrine.
Why it happens
Strong CYP3A4 inhibition decreases metabolic clearance of the estrogen and bazedoxifene components.
What to do
Avoid the combination where possible and use an alternative therapy for menopausal symptoms or Cushing syndrome. If co-administered, monitor for estrogenic adverse effects and abnormal bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Levoketoconazole?
MediHelp rates the interaction as major. Bazedoxifene-conjugated estrogens and Levoketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levoketoconazole is a strong CYP3A4 inhibitor and can substantially increase exposure to the estrogen component and possibly bazedoxifene. This raises the risk of estrogen-related adverse effects, including endometrial stimulation and thromboembolic concerns.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Levoketoconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an alternative therapy for menopausal symptoms or Cushing syndrome. If co-administered, monitor for estrogenic adverse effects and abnormal bleeding.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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