Drug interactions
Bazedoxifene-conjugated estrogens + Nevirapine
Severity: Moderate
Bazedoxifene-conjugated estrogens and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and can reduce estrogen and bazedoxifene exposure. This may reduce symptom relief and, importantly, weaken the endometrial protection provided by bazedoxifene, with a risk of breakthrough bleeding.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Nevirapine belongs to Anti Virals.
Why it happens
Induction of hepatic CYP3A4 by nevirapine accelerates metabolism of estrogens and bazedoxifene.
What to do
Monitor for recurrence of vasomotor symptoms and for unexpected vaginal bleeding, and evaluate any bleeding. Consider an alternative regimen if efficacy or endometrial safety is in doubt.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Nevirapine?
MediHelp rates the interaction as moderate. Bazedoxifene-conjugated estrogens and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine induces CYP3A4 and can reduce estrogen and bazedoxifene exposure. This may reduce symptom relief and, importantly, weaken the endometrial protection provided by bazedoxifene, with a risk of breakthrough bleeding.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for recurrence of vasomotor symptoms and for unexpected vaginal bleeding, and evaluate any bleeding. Consider an alternative regimen if efficacy or endometrial safety is in doubt.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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