Drug interactions
Beclomethasone + Leflunomide
Severity: Minor
Beclomethasone and Leflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leflunomide can cause bone marrow suppression and infection risk, and combining it with other immunosuppressants may add to this. Inhaled beclomethasone has low systemic exposure, so the additional risk is small.
What this interaction means in plain words
Beclomethasone and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Beclomethasone belongs to Respiratory; Leflunomide belongs to Musculoskeletal.
Why it happens
Additive immunosuppression; systemic exposure from inhaled beclomethasone is low.
What to do
Continue routine blood count and liver monitoring for leflunomide; no change to inhaled beclomethasone is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Beclomethasone
Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Beclomethasone with Leflunomide?
MediHelp rates the interaction as minor. Beclomethasone and Leflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leflunomide can cause bone marrow suppression and infection risk, and combining it with other immunosuppressants may add to this. Inhaled beclomethasone has low systemic exposure, so the additional risk is small.
How serious is the interaction between Beclomethasone and Leflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue routine blood count and liver monitoring for leflunomide; no change to inhaled beclomethasone is usually needed.
What other medicines interact with Beclomethasone?
MediHelp also lists interactions of Beclomethasone with, for example, Corticorelin, Macimorelin, Sipuleucel-t. The full list is on the Beclomethasone page.
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