Drug interactions
Bedaquiline + Granisetron
Severity: Major
Bedaquiline and Granisetron: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bedaquiline carries a labeled warning for QT prolongation, and granisetron adds a further QT-prolonging effect. The combination may increase the risk of torsades de pointes, and bedaquiline's very long terminal half-life prolongs exposure.
What this interaction means in plain words
Bedaquiline and Granisetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bedaquiline belongs to Anti Bacterial; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid if an alternative antiemetic is available. If co-use is necessary, obtain baseline and periodic ECGs and correct electrolyte abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Granisetron?
MediHelp rates the interaction as major. Bedaquiline and Granisetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bedaquiline carries a labeled warning for QT prolongation, and granisetron adds a further QT-prolonging effect. The combination may increase the risk of torsades de pointes, and bedaquiline's very long terminal half-life prolongs exposure.
How serious is the interaction between Bedaquiline and Granisetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative antiemetic is available. If co-use is necessary, obtain baseline and periodic ECGs and correct electrolyte abnormalities.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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