Drug interactions
Bedaquiline + Moxifloxacin
Severity: Major
Bedaquiline and Moxifloxacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QTc interval, and together the effect is additive. This raises the risk of torsades de pointes, especially with electrolyte disturbances, bradycardia or heart disease.
What this interaction means in plain words
Bedaquiline and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bedaquiline belongs to Anti Bacterial; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation through cardiac repolarization (hERG potassium channel) effects.
What to do
Obtain a baseline ECG and repeat it regularly during co-therapy, and correct potassium, magnesium and calcium. Stop or change therapy if QTc becomes markedly prolonged or the patient has arrhythmia symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Moxifloxacin?
MediHelp rates the interaction as major. Bedaquiline and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QTc interval, and together the effect is additive. This raises the risk of torsades de pointes, especially with electrolyte disturbances, bradycardia or heart disease.
How serious is the interaction between Bedaquiline and Moxifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it regularly during co-therapy, and correct potassium, magnesium and calcium. Stop or change therapy if QTc becomes markedly prolonged or the patient has arrhythmia symptoms.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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