Drug interactions
Bedaquiline + Oxaliplatin
Severity: Major
Bedaquiline and Oxaliplatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both oxaliplatin and bedaquiline can prolong the QT interval, so using them together may add to the risk of torsades de pointes. Oxaliplatin-related electrolyte disturbances such as hypokalemia and hypomagnesemia can increase this risk further.
What this interaction means in plain words
Bedaquiline and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bedaquiline belongs to Anti Bacterial; Oxaliplatin belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization (QT interval) through pharmacodynamic effects.
What to do
Obtain a baseline ECG and correct potassium, magnesium and calcium before starting. Repeat ECGs during co-treatment and consider an alternative agent if QTc exceeds 500 ms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Oxaliplatin?
MediHelp rates the interaction as major. Bedaquiline and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both oxaliplatin and bedaquiline can prolong the QT interval, so using them together may add to the risk of torsades de pointes. Oxaliplatin-related electrolyte disturbances such as hypokalemia and hypomagnesemia can increase this risk further.
How serious is the interaction between Bedaquiline and Oxaliplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium, magnesium and calcium before starting. Repeat ECGs during co-treatment and consider an alternative agent if QTc exceeds 500 ms.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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