Drug interactions
Belzutifan + Ticlopidine
Severity: Moderate
Belzutifan and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine strongly inhibits CYP2C19, which contributes to belzutifan clearance. Higher belzutifan exposure can worsen anemia and hypoxia.
What this interaction means in plain words
Belzutifan and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belzutifan belongs to Miscellaneous; Ticlopidine belongs to Cardiovascular.
Why it happens
Inhibition of CYP2C19-mediated metabolism of belzutifan by ticlopidine.
What to do
Monitor hemoglobin and oxygen saturation and reduce the belzutifan dose if toxicity develops. Consider an alternative antiplatelet such as one without CYP2C19 inhibition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticlopidine
Other interactions of Belzutifan
Frequently asked questions
Can I take Belzutifan with Ticlopidine?
MediHelp rates the interaction as moderate. Belzutifan and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticlopidine strongly inhibits CYP2C19, which contributes to belzutifan clearance. Higher belzutifan exposure can worsen anemia and hypoxia.
How serious is the interaction between Belzutifan and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and oxygen saturation and reduce the belzutifan dose if toxicity develops. Consider an alternative antiplatelet such as one without CYP2C19 inhibition.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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