Drug interactions
Benazepril + Bumetanide
Severity: Moderate
Benazepril and Bumetanide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an ACE inhibitor with a loop diuretic can cause marked hypotension, especially after the first dose in volume-depleted patients. Renal function may worsen.
What this interaction means in plain words
Benazepril and Bumetanide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Bumetanide belongs to Cardiovascular.
Why it happens
Additive hemodynamic effects: diuretic volume depletion increases dependence on angiotensin II, which ACE inhibition blocks.
What to do
Start benazepril at a low dose, consider reducing bumetanide temporarily, and monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Bumetanide?
MediHelp rates the interaction as moderate. Benazepril and Bumetanide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an ACE inhibitor with a loop diuretic can cause marked hypotension, especially after the first dose in volume-depleted patients. Renal function may worsen.
How serious is the interaction between Benazepril and Bumetanide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start benazepril at a low dose, consider reducing bumetanide temporarily, and monitor blood pressure, creatinine and potassium.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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