Drug interactions
Benazepril + Canagliflozin
Severity: Moderate
Benazepril and Canagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The legacy concern about hyperkalemia is not well supported, since canagliflozin does not generally raise potassium meaningfully. The real interaction is additive volume depletion and hypotension, with possible effects on renal function, when combined with an ACE inhibitor.
What this interaction means in plain words
Benazepril and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Canagliflozin belongs to Endocrine.
Why it happens
SGLT2 inhibitor-induced osmotic diuresis and natriuresis add to ACE inhibitor effects on blood pressure and glomerular filtration.
What to do
Assess volume status and monitor blood pressure, creatinine and potassium after starting canagliflozin; reduce diuretic or antihypertensive doses if volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Benazepril with Canagliflozin?
MediHelp rates the interaction as moderate. Benazepril and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The legacy concern about hyperkalemia is not well supported, since canagliflozin does not generally raise potassium meaningfully. The real interaction is additive volume depletion and hypotension, with possible effects on renal function, when combined with an ACE inhibitor.
How serious is the interaction between Benazepril and Canagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and monitor blood pressure, creatinine and potassium after starting canagliflozin; reduce diuretic or antihypertensive doses if volume depletion occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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