Drug interactions
Benazepril + Duloxetine
Severity: Minor
Benazepril and Duloxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine can cause orthostatic hypotension and dizziness, which may add to the blood pressure lowering effect of benazepril. The effect is usually modest but can cause falls in older or volume-depleted patients.
What this interaction means in plain words
Benazepril and Duloxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Benazepril belongs to Cardiovascular; Duloxetine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotensive effects.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting duloxetine. Reduce the antihypertensive dose only if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Benazepril with Duloxetine?
MediHelp rates the interaction as minor. Benazepril and Duloxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Duloxetine can cause orthostatic hypotension and dizziness, which may add to the blood pressure lowering effect of benazepril. The effect is usually modest but can cause falls in older or volume-depleted patients.
How serious is the interaction between Benazepril and Duloxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting duloxetine. Reduce the antihypertensive dose only if symptomatic hypotension occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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