Drug interactions
Benazepril + Finerenone
Severity: Major
Benazepril and Finerenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both finerenone and ACE inhibitors raise serum potassium, so combined use increases the risk of hyperkalemia, especially with reduced kidney function. The combination is used deliberately in diabetic kidney disease but needs structured monitoring.
What this interaction means in plain words
Benazepril and Finerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Benazepril belongs to Cardiovascular; Finerenone belongs to Cardiovascular.
Why it happens
Additive hyperkalemia from mineralocorticoid receptor antagonism and reduced angiotensin II mediated aldosterone secretion.
What to do
Measure serum potassium and eGFR before starting and during therapy, and adjust, interrupt or withhold finerenone per labeled potassium thresholds. Avoid other potassium-raising agents and supplements.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Benazepril with Finerenone?
MediHelp rates the interaction as major. Benazepril and Finerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both finerenone and ACE inhibitors raise serum potassium, so combined use increases the risk of hyperkalemia, especially with reduced kidney function. The combination is used deliberately in diabetic kidney disease but needs structured monitoring.
How serious is the interaction between Benazepril and Finerenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum potassium and eGFR before starting and during therapy, and adjust, interrupt or withhold finerenone per labeled potassium thresholds. Avoid other potassium-raising agents and supplements.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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