Drug interactions
Benazepril + Hydrochlorothiazide
Severity: Moderate
Benazepril and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination is often used deliberately, but first-dose hypotension and acute kidney injury can occur, particularly with volume depletion. ACE inhibitors also offset thiazide-related potassium loss.
What this interaction means in plain words
Benazepril and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering, with ACE inhibition reducing glomerular filtration pressure in a volume-depleted patient.
What to do
Monitor blood pressure, serum creatinine and potassium after starting or changing doses. Consider reducing or temporarily holding the diuretic when starting the ACE inhibitor in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Benazepril and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination is often used deliberately, but first-dose hypotension and acute kidney injury can occur, particularly with volume depletion. ACE inhibitors also offset thiazide-related potassium loss.
How serious is the interaction between Benazepril and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting or changing doses. Consider reducing or temporarily holding the diuretic when starting the ACE inhibitor in volume-depleted patients.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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