Drug interactions
Benazepril + Risperidone
Severity: Moderate
Benazepril and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone has alpha-1 blocking activity that can produce orthostatic hypotension. Together with benazepril, hypotension, dizziness, and falls may be more likely, particularly in older adults.
What this interaction means in plain words
Benazepril and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Risperidone belongs to Central Nervous System.
Why it happens
Additive hypotension from alpha-1 adrenergic antagonism and ACE inhibition.
What to do
Titrate risperidone slowly and monitor orthostatic blood pressure. Lower the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Benazepril with Risperidone?
MediHelp rates the interaction as moderate. Benazepril and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone has alpha-1 blocking activity that can produce orthostatic hypotension. Together with benazepril, hypotension, dizziness, and falls may be more likely, particularly in older adults.
How serious is the interaction between Benazepril and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate risperidone slowly and monitor orthostatic blood pressure. Lower the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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