Drug interactions
Benazepril + Temsirolimus
Severity: Moderate
Benazepril and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus, an mTOR inhibitor, has been associated with angioedema, and the risk appears higher when given with ACE inhibitors. Swelling of the face, tongue, or airway can be serious.
What this interaction means in plain words
Benazepril and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
Probably additive impairment of bradykinin metabolism via mTOR inhibition and ACE inhibition.
What to do
Counsel patients to report swelling immediately. Stop the ACE inhibitor and treat if angioedema develops, and consider an alternative antihypertensive class.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Benazepril with Temsirolimus?
MediHelp rates the interaction as moderate. Benazepril and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus, an mTOR inhibitor, has been associated with angioedema, and the risk appears higher when given with ACE inhibitors. Swelling of the face, tongue, or airway can be serious.
How serious is the interaction between Benazepril and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report swelling immediately. Stop the ACE inhibitor and treat if angioedema develops, and consider an alternative antihypertensive class.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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