Drug interactions
Bendamustine + Givosiran
Severity: Moderate
Bendamustine and Givosiran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP1A2 activity, and bendamustine is partly cleared by CYP1A2, though its main elimination is hydrolysis. Exposure to the parent drug may rise modestly, and the active metabolites are formed in small amounts.
What this interaction means in plain words
Bendamustine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bendamustine belongs to Oncology; Givosiran belongs to Miscellaneous.
Why it happens
Givosiran inhibits CYP1A2, reducing the metabolism of bendamustine.
What to do
Monitor for increased myelosuppression and other bendamustine toxicity. Check blood counts more often during the combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bendamustine
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Bendamustine with Givosiran?
MediHelp rates the interaction as moderate. Bendamustine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can reduce CYP1A2 activity, and bendamustine is partly cleared by CYP1A2, though its main elimination is hydrolysis. Exposure to the parent drug may rise modestly, and the active metabolites are formed in small amounts.
How serious is the interaction between Bendamustine and Givosiran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased myelosuppression and other bendamustine toxicity. Check blood counts more often during the combination.
What other medicines interact with Bendamustine?
MediHelp also lists interactions of Bendamustine with, for example, Axicabtagene ciloleucel, Brexucabtagene autoleucel, Chlorambucil. The full list is on the Bendamustine page.
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