Drug interactions
Bendroflumethiazide + Ertugliflozin-sitagliptin
Severity: Minor
Bendroflumethiazide and Ertugliflozin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose, particularly at higher doses, which may partly offset the glucose-lowering effect of ertugliflozin and sitagliptin. Thiazides may also add to the volume depletion caused by ertugliflozin's osmotic diuresis. The effect is usually modest at low antihypertensive doses.
What this interaction means in plain words
Bendroflumethiazide and Ertugliflozin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazides cause potassium loss and reduced insulin secretion and peripheral insulin sensitivity, opposing antihyperglycemic action; additive diuresis with SGLT2 inhibition.
What to do
Monitor glycemic control and HbA1c when starting or increasing the thiazide dose. Assess volume status, blood pressure and renal function, and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ertugliflozin-sitagliptin
Frequently asked questions
Can I take Bendroflumethiazide with Ertugliflozin-sitagliptin?
MediHelp rates the interaction as minor. Bendroflumethiazide and Ertugliflozin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose, particularly at higher doses, which may partly offset the glucose-lowering effect of ertugliflozin and sitagliptin. Thiazides may also add to the volume depletion caused by ertugliflozin's osmotic diuresis. The effect is usually modest at low antihypertensive doses.
How serious is the interaction between Bendroflumethiazide and Ertugliflozin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and HbA1c when starting or increasing the thiazide dose. Assess volume status, blood pressure and renal function, and adjust antidiabetic therapy if needed.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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