Drug interactions
Benazepril + Ertugliflozin-sitagliptin
Severity: Moderate
Benazepril and Ertugliflozin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DPP-4 inhibitors such as sitagliptin and ACE inhibitors both reduce breakdown of substance P and bradykinin, which can raise angioedema risk. The absolute risk is low but the event may be serious.
What this interaction means in plain words
Benazepril and Ertugliflozin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Ertugliflozin-sitagliptin belongs to Endocrine.
Why it happens
Both drugs reduce degradation of bradykinin and substance P, additively promoting angioedema.
What to do
Counsel patients to report swelling of face, lips or tongue, and stop the offending drug if angioedema occurs. Monitor blood pressure and renal function with the ACE inhibitor and SGLT2 inhibitor combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Benazepril with Ertugliflozin-sitagliptin?
MediHelp rates the interaction as moderate. Benazepril and Ertugliflozin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. DPP-4 inhibitors such as sitagliptin and ACE inhibitors both reduce breakdown of substance P and bradykinin, which can raise angioedema risk. The absolute risk is low but the event may be serious.
How serious is the interaction between Benazepril and Ertugliflozin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report swelling of face, lips or tongue, and stop the offending drug if angioedema occurs. Monitor blood pressure and renal function with the ACE inhibitor and SGLT2 inhibitor combination.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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