Drug interactions
Asenapine + Ertugliflozin-sitagliptin
Severity: Moderate
Asenapine and Ertugliflozin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can cause hyperglycemia and weight gain, which may offset glucose-lowering therapy. Glycemic control may deteriorate.
What this interaction means in plain words
Asenapine and Ertugliflozin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Ertugliflozin-sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: antipsychotic-related insulin resistance and hyperglycemia.
What to do
Monitor blood glucose and HbA1c, and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Ertugliflozin-sitagliptin?
MediHelp rates the interaction as moderate. Asenapine and Ertugliflozin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can cause hyperglycemia and weight gain, which may offset glucose-lowering therapy. Glycemic control may deteriorate.
How serious is the interaction between Asenapine and Ertugliflozin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c, and adjust antidiabetic therapy if control worsens.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Benazepril. The full list is on the Ertugliflozin-sitagliptin page.
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