Drug reference
ertugliflozin-sitagliptin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Endocrine (Miscellaneous(Hormones))
Mechanism of action
Sitagliptin: Dipeptyl peptidase-IV (DPP-4) inhibitor; increases and prolongs incretin hormone activity, which is inactivated by DPP-4 enzyme; incretins increase insulin release and synthesis from pancreatic beta cells and reduce glucagon secretion from pancreatic alpha cells
Ertugliflozin: Selective sodium-glucose transporter-2 (SGLT2) inhibitor; lowers the renal glucose threshold (ie, the plasma glucose concentration which exceed the maximum glucose reabsorption capacity of the kidney); lowering the renal glucose threshold results in increased urinary glucose excretion
Common side effects
- Female genital mycotic infections
- Headaches
- Male genital mycotic infections
- Volume depletion adverse effects
- Vaginal pruritus
- Urinary tract infection
Contraindications
- Hypersensitivity to drugs or excipients; reactions such as angioedema or anaphylaxis have occurred Severe renal impairment (<30 mL/min/1.73 m2), end-stage renal disease, or dialysis
Related conditions
Frequently asked questions
What drug class is ertugliflozin-sitagliptin?
ertugliflozin-sitagliptin belongs to: Endocrine.
How does ertugliflozin-sitagliptin work?
Sitagliptin: Dipeptyl peptidase-IV (DPP-4) inhibitor; increases and prolongs incretin hormone activity, which is inactivated by DPP-4 enzyme; incretins increase insulin release and synthesis from pancreatic beta cells and reduce glucagon secretion from pancreatic alpha cells Ertugliflozin: Selective sodium-glucose transporter-2 (SGLT2) inhibitor; lowers the renal glucose threshold (ie, the plasma glucose concentration which exceed the maximum glucose reabsorption capacity of the kidney); lowering the renal glucose threshold results in increased urinary glucose excretion
What are the common side effects of ertugliflozin-sitagliptin?
Female genital mycotic infections, Headaches, Male genital mycotic infections, Volume depletion adverse effects, Vaginal pruritus, Urinary tract infection
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