Drug interactions
Aripiprazole + Ertugliflozin-sitagliptin
Severity: Moderate
Aripiprazole and Ertugliflozin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole can cause hyperglycemia and metabolic changes, which may counteract the glucose-lowering effects of ertugliflozin and sitagliptin. Glycemic control may worsen.
What this interaction means in plain words
Aripiprazole and Ertugliflozin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Ertugliflozin-sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: antipsychotic-related insulin resistance and hyperglycemia.
What to do
Monitor blood glucose and HbA1c and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Ertugliflozin-sitagliptin?
MediHelp rates the interaction as moderate. Aripiprazole and Ertugliflozin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aripiprazole can cause hyperglycemia and metabolic changes, which may counteract the glucose-lowering effects of ertugliflozin and sitagliptin. Glycemic control may worsen.
How serious is the interaction between Aripiprazole and Ertugliflozin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c and adjust antidiabetic therapy as needed.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Asenapine, Benazepril. The full list is on the Ertugliflozin-sitagliptin page.
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