Drug interactions
Captopril + Ertugliflozin-sitagliptin
Severity: Moderate
Captopril and Ertugliflozin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sitagliptin and ACE inhibitors both impair breakdown of bradykinin and substance P, which may increase the risk of angioedema. The absolute risk is low but the event can be serious.
What this interaction means in plain words
Captopril and Ertugliflozin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Ertugliflozin-sitagliptin belongs to Endocrine.
Why it happens
Both drugs reduce degradation of bradykinin and substance P, additively promoting angioedema.
What to do
Counsel patients to report swelling of face, lips or tongue and discontinue the drugs if angioedema occurs. Monitor volume status and renal function given ertugliflozin plus ACE inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Ertugliflozin-sitagliptin?
MediHelp rates the interaction as moderate. Captopril and Ertugliflozin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sitagliptin and ACE inhibitors both impair breakdown of bradykinin and substance P, which may increase the risk of angioedema. The absolute risk is low but the event can be serious.
How serious is the interaction between Captopril and Ertugliflozin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report swelling of face, lips or tongue and discontinue the drugs if angioedema occurs. Monitor volume status and renal function given ertugliflozin plus ACE inhibitor.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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