Drug interactions
Benzathine penicillin g + Leniolisib
Severity: Minor
Benzathine penicillin g and Leniolisib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits OATP1B1 and OATP1B3, which could in theory increase levels of substrates. Penicillin G is not a clinically important OATP substrate and has a wide safety margin, so a meaningful effect is unlikely.
What this interaction means in plain words
Benzathine penicillin g and Leniolisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Benzathine penicillin g belongs to Anti Bacterial; Leniolisib belongs to Miscellaneous.
Why it happens
Theoretical inhibition of hepatic OATP1B1/1B3 uptake by leniolisib.
What to do
No dose change is needed. Monitor for penicillin adverse effects only if other risk factors exist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Benzathine penicillin g
- Benzathine penicillin g + Cholera vaccine Moderate
- Benzathine penicillin g + Microbiota Moderate
- Benzathine penicillin g + Omadacycline Moderate
- Benzathine penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Amifampridine + Benzathine penicillin g Minor
Other interactions of Leniolisib
Frequently asked questions
Can I take Benzathine penicillin g with Leniolisib?
MediHelp rates the interaction as minor. Benzathine penicillin g and Leniolisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leniolisib inhibits OATP1B1 and OATP1B3, which could in theory increase levels of substrates. Penicillin G is not a clinically important OATP substrate and has a wide safety margin, so a meaningful effect is unlikely.
How serious is the interaction between Benzathine penicillin g and Leniolisib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for penicillin adverse effects only if other risk factors exist.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Microbiota, Omadacycline. The full list is on the Benzathine penicillin g page.
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