Drug interactions
Benzathine penicillin g + Sarecycline
Severity: Minor
Benzathine penicillin g and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracycline-class bacteriostatic agents may reduce the bactericidal effect of penicillins. With sarecycline's narrow-spectrum use in acne, the clinical impact is likely small and largely theoretical.
What this interaction means in plain words
Benzathine penicillin g and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Benzathine penicillin g belongs to Anti Bacterial; Sarecycline belongs to Anti Bacterial.
Why it happens
Inhibition of bacterial growth by the tetracycline may reduce activity of cell-wall-active penicillin.
What to do
Monitor clinical response to penicillin therapy, particularly in serious infections. Consider deferring sarecycline until penicillin treatment is completed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Benzathine penicillin g
- Benzathine penicillin g + Cholera vaccine Moderate
- Benzathine penicillin g + Microbiota Moderate
- Benzathine penicillin g + Omadacycline Moderate
- Benzathine penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Amifampridine + Benzathine penicillin g Minor
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Benzathine penicillin g with Sarecycline?
MediHelp rates the interaction as minor. Benzathine penicillin g and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tetracycline-class bacteriostatic agents may reduce the bactericidal effect of penicillins. With sarecycline's narrow-spectrum use in acne, the clinical impact is likely small and largely theoretical.
How serious is the interaction between Benzathine penicillin g and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to penicillin therapy, particularly in serious infections. Consider deferring sarecycline until penicillin treatment is completed.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Microbiota, Omadacycline. The full list is on the Benzathine penicillin g page.
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