Drug interactions
Berotralstat + Ivermectin
Severity: Minor
Berotralstat and Ivermectin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein and may increase ivermectin exposure. Higher ivermectin levels may increase the risk of adverse effects, although ivermectin has a wide safety margin at usual doses.
What this interaction means in plain words
Berotralstat and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Berotralstat belongs to Miscellaneous; Ivermectin belongs to Anti Parasitic.
Why it happens
Berotralstat inhibits P-glycoprotein efflux of ivermectin.
What to do
No routine dose change is needed for standard antiparasitic dosing. Monitor for neurologic or gastrointestinal adverse effects with repeated or high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Ivermectin?
MediHelp rates the interaction as minor. Berotralstat and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Berotralstat inhibits P-glycoprotein and may increase ivermectin exposure. Higher ivermectin levels may increase the risk of adverse effects, although ivermectin has a wide safety margin at usual doses.
How serious is the interaction between Berotralstat and Ivermectin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for standard antiparasitic dosing. Monitor for neurologic or gastrointestinal adverse effects with repeated or high doses.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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