Drug interactions
Berotralstat + Posaconazole
Severity: Moderate
Berotralstat and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs interact via P-glycoprotein, with posaconazole potentially raising berotralstat levels and berotralstat potentially raising posaconazole levels. Berotralstat is also a QT-prolonging drug at higher doses, as is posaconazole.
What this interaction means in plain words
Berotralstat and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Posaconazole belongs to Anti Fungals.
Why it happens
Mutual P-glycoprotein inhibition and substrate competition increases exposure to both drugs.
What to do
Monitor for berotralstat adverse effects such as gastrointestinal upset and QT prolongation, and for posaconazole toxicity. Obtain an ECG if other QT risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Posaconazole?
MediHelp rates the interaction as moderate. Berotralstat and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs interact via P-glycoprotein, with posaconazole potentially raising berotralstat levels and berotralstat potentially raising posaconazole levels. Berotralstat is also a QT-prolonging drug at higher doses, as is posaconazole.
How serious is the interaction between Berotralstat and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for berotralstat adverse effects such as gastrointestinal upset and QT prolongation, and for posaconazole toxicity. Obtain an ECG if other QT risk factors exist.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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