Drug interactions
Bevacizumab + Liposomal doxorubicin
Severity: Moderate
Bevacizumab and Liposomal doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can impair cardiac function, and bevacizumab may add to anthracycline-related heart failure and left ventricular dysfunction. Bevacizumab also causes hypertension, which adds to cardiac strain. The risk is greater with prior cardiac disease or high cumulative anthracycline exposure.
What this interaction means in plain words
Bevacizumab and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bevacizumab belongs to Oncology; Liposomal doxorubicin belongs to Oncology.
Why it happens
Additive cardiotoxicity through anthracycline myocardial injury and VEGF inhibition with associated hypertension.
What to do
Assess baseline left ventricular ejection fraction and repeat periodically. Control blood pressure and track the cumulative anthracycline dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Bevacizumab
- Bevacizumab + Sunitinib Major
- Bevacizumab + Daunorubicin Moderate
- Bevacizumab + Dengue vaccine Moderate
- Bevacizumab + Doxorubicin Moderate
- Bevacizumab + Doxorubicin liposomal Moderate
- Bevacizumab + Efgartigimod / hyaluronidase sc Moderate
Frequently asked questions
Can I take Bevacizumab with Liposomal doxorubicin?
MediHelp rates the interaction as moderate. Bevacizumab and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can impair cardiac function, and bevacizumab may add to anthracycline-related heart failure and left ventricular dysfunction. Bevacizumab also causes hypertension, which adds to cardiac strain. The risk is greater with prior cardiac disease or high cumulative anthracycline exposure.
How serious is the interaction between Bevacizumab and Liposomal doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess baseline left ventricular ejection fraction and repeat periodically. Control blood pressure and track the cumulative anthracycline dose.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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