Drug interactions
Bexagliflozin + Insulin degludec-insulin aspart
Severity: Moderate
Bexagliflozin and Insulin degludec-insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexagliflozin with insulin increases hypoglycemia risk, and SGLT2 inhibition also carries a ketoacidosis risk in insulin-treated patients.
What this interaction means in plain words
Bexagliflozin and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexagliflozin belongs to Endocrine; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Additive glucose lowering via insulin-independent urinary glucose excretion.
What to do
Consider reducing the insulin dose when starting bexagliflozin and monitor glucose. Avoid large abrupt insulin reductions and check ketones if unwell.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Bexagliflozin
- Bexagliflozin + Carbamazepine Moderate
- Bexagliflozin + Chlorpropamide Moderate
- Bexagliflozin + Glibenclamide Moderate
- Bexagliflozin + Gliclazide Moderate
- Bexagliflozin + Glimepiride Moderate
- Bexagliflozin + Glimepiride-pioglitazone Moderate
Frequently asked questions
Can I take Bexagliflozin with Insulin degludec-insulin aspart?
MediHelp rates the interaction as moderate. Bexagliflozin and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexagliflozin with insulin increases hypoglycemia risk, and SGLT2 inhibition also carries a ketoacidosis risk in insulin-treated patients.
How serious is the interaction between Bexagliflozin and Insulin degludec-insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin dose when starting bexagliflozin and monitor glucose. Avoid large abrupt insulin reductions and check ketones if unwell.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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