Drug interactions
Bicalutamide + Crizotinib
Severity: Minor
Bicalutamide and Crizotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bicalutamide is a weak CYP3A4 inhibitor and could marginally raise crizotinib levels. Crizotinib has dose-related hepatotoxicity, bradycardia and QT effects, but a clinically relevant change is unlikely.
What this interaction means in plain words
Bicalutamide and Crizotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Crizotinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by bicalutamide reduces crizotinib metabolism.
What to do
Monitor liver enzymes and heart rate/ECG per routine crizotinib monitoring; no dose change is generally needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bicalutamide and Crizotinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Bicalutamide with Crizotinib?
MediHelp rates the interaction as minor. Bicalutamide and Crizotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bicalutamide is a weak CYP3A4 inhibitor and could marginally raise crizotinib levels. Crizotinib has dose-related hepatotoxicity, bradycardia and QT effects, but a clinically relevant change is unlikely.
How serious is the interaction between Bicalutamide and Crizotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and heart rate/ECG per routine crizotinib monitoring; no dose change is generally needed.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
