Drug interactions
Bicalutamide + Daridorexant
Severity: Minor
Bicalutamide and Daridorexant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daridorexant is cleared mainly by CYP3A4, and moderate inhibitors raise its exposure and the risk of next-day somnolence. Bicalutamide is only a weak CYP3A4 inhibitor in vitro and clinical relevance is uncertain, so any effect is likely small.
What this interaction means in plain words
Bicalutamide and Daridorexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Daridorexant belongs to Central Nervous System.
Why it happens
Possible weak inhibition of CYP3A4-mediated daridorexant metabolism by bicalutamide.
What to do
No routine dose change is needed; keep daridorexant at or below 25 mg nightly if a clinically meaningful CYP3A4 inhibitor effect is suspected and monitor for daytime sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Daridorexant
Frequently asked questions
Can I take Bicalutamide with Daridorexant?
MediHelp rates the interaction as minor. Bicalutamide and Daridorexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Daridorexant is cleared mainly by CYP3A4, and moderate inhibitors raise its exposure and the risk of next-day somnolence. Bicalutamide is only a weak CYP3A4 inhibitor in vitro and clinical relevance is uncertain, so any effect is likely small.
How serious is the interaction between Bicalutamide and Daridorexant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; keep daridorexant at or below 25 mg nightly if a clinically meaningful CYP3A4 inhibitor effect is suspected and monitor for daytime sedation.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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