Drug interactions
Bicalutamide + Ivacaftor
Severity: Minor
Bicalutamide and Ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor exposure rises with CYP3A4 inhibitors, but bicalutamide is only a weak inhibitor so a significant increase is unlikely. The effect is mainly theoretical.
What this interaction means in plain words
Bicalutamide and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Ivacaftor belongs to Miscellaneous.
Why it happens
Weak CYP3A4 inhibition by bicalutamide may reduce ivacaftor clearance.
What to do
No dose reduction is needed; monitor liver enzymes and adverse effects such as headache.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Bicalutamide with Ivacaftor?
MediHelp rates the interaction as minor. Bicalutamide and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor exposure rises with CYP3A4 inhibitors, but bicalutamide is only a weak inhibitor so a significant increase is unlikely. The effect is mainly theoretical.
How serious is the interaction between Bicalutamide and Ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose reduction is needed; monitor liver enzymes and adverse effects such as headache.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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