Drug interactions
Bicalutamide + Mefloquine
Severity: Minor
Bicalutamide and Mefloquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bicalutamide is only a weak CYP3A4 inhibitor in vitro, and no meaningful rise in mefloquine levels has been shown. Any effect is expected to be small.
What this interaction means in plain words
Bicalutamide and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Mefloquine belongs to Anti Parasitic.
Why it happens
Possible weak CYP3A4 inhibition by bicalutamide; clinical relevance is unestablished.
What to do
No routine adjustment is needed. Monitor for neuropsychiatric adverse effects of mefloquine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Frequently asked questions
Can I take Bicalutamide with Mefloquine?
MediHelp rates the interaction as minor. Bicalutamide and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bicalutamide is only a weak CYP3A4 inhibitor in vitro, and no meaningful rise in mefloquine levels has been shown. Any effect is expected to be small.
How serious is the interaction between Bicalutamide and Mefloquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for neuropsychiatric adverse effects of mefloquine.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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