Drug interactions
Bismuth subsalicylate + Metoclopramide
Severity: Minor
Bismuth subsalicylate and Metoclopramide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bismuth subsalicylate has mild antimotility and antisecretory effects that are unlikely to meaningfully change metoclopramide effect. Any reduction in response is theoretical and small.
What this interaction means in plain words
Bismuth subsalicylate and Metoclopramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bismuth subsalicylate belongs to Gastrointestinal Tract; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Possible modest opposition to prokinetic action through reduced GI motility; not well established.
What to do
No routine adjustment is required. Reassess if the antiemetic or prokinetic response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoclopramide
Other interactions of Bismuth subsalicylate
- Bismuth subsalicylate + Dichlorphenamide Major
- Bismuth subsalicylate + Warfarin Major
- Acetylsalicylic acid + Bismuth subsalicylate Moderate
- Amlodipine-benazepril + Bismuth subsalicylate Moderate
- Aspirin / citric acid / sodium bicarbonate + Bismuth subsalicylate Moderate
- Aspirin rectal + Bismuth subsalicylate Moderate
Frequently asked questions
Can I take Bismuth subsalicylate with Metoclopramide?
MediHelp rates the interaction as minor. Bismuth subsalicylate and Metoclopramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bismuth subsalicylate has mild antimotility and antisecretory effects that are unlikely to meaningfully change metoclopramide effect. Any reduction in response is theoretical and small.
How serious is the interaction between Bismuth subsalicylate and Metoclopramide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required. Reassess if the antiemetic or prokinetic response is inadequate.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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