Drug interactions
Bortezomib + Clarithromycin
Severity: Moderate
Bortezomib and Clarithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may raise bortezomib exposure because bortezomib is partly cleared by CYP3A4. Higher levels could increase the risk of peripheral neuropathy, myelosuppression and gastrointestinal toxicity.
What this interaction means in plain words
Bortezomib and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Clarithromycin belongs to Anti Bacterial.
Why it happens
Clarithromycin inhibits CYP3A4, reducing the metabolism of bortezomib.
What to do
Monitor patients closely for bortezomib toxicity such as neuropathy, thrombocytopenia and GI effects, and reduce the dose if needed. Consider an antibiotic without CYP3A4 inhibition, such as azithromycin, if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Clarithromycin?
MediHelp rates the interaction as moderate. Bortezomib and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin may raise bortezomib exposure because bortezomib is partly cleared by CYP3A4. Higher levels could increase the risk of peripheral neuropathy, myelosuppression and gastrointestinal toxicity.
How serious is the interaction between Bortezomib and Clarithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor patients closely for bortezomib toxicity such as neuropathy, thrombocytopenia and GI effects, and reduce the dose if needed. Consider an antibiotic without CYP3A4 inhibition, such as azithromycin, if appropriate.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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