Drug interactions
Bortezomib + Clobazam
Severity: Minor
Bortezomib and Clobazam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bortezomib is not a clinically established CYP2C19 inhibitor, so a meaningful rise in clobazam or N-desmethylclobazam exposure is not expected. The interaction is theoretical.
What this interaction means in plain words
Bortezomib and Clobazam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bortezomib belongs to Oncology; Clobazam belongs to Central Nervous System.
Why it happens
Not established; theoretical CYP2C19 inhibition.
What to do
No empirical dose change is needed. Monitor for excessive sedation and adjust clobazam if it occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Bortezomib with Clobazam?
MediHelp rates the interaction as minor. Bortezomib and Clobazam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bortezomib is not a clinically established CYP2C19 inhibitor, so a meaningful rise in clobazam or N-desmethylclobazam exposure is not expected. The interaction is theoretical.
How serious is the interaction between Bortezomib and Clobazam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for excessive sedation and adjust clobazam if it occurs.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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